New therapeutic targets in transfusion-dependent and -independent thalassemia
نویسندگان
چکیده
منابع مشابه
Prevalence of Alloantibodies and Autoantibodies in Transfusion Dependent Thalassemia Patients
Background: The development of anti-red blood cell alloantibodies remains a major problem in transfusion of blood in thalassemia major patients. Also, Autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. We studied the frequency of red blood cell alloimmunization and autoimmunization among thalassemia patients who received regular transfusions in Ilam province...
متن کاملBone density in transfusion dependent thalassemia patients in Urmia, Iran
Background Patients with thalassemia major and intermedia are susceptible to osteopenia and osteoporosis. The mechanism of osteoporosis in these patients is multifactorial. Transfusion related iron overload in endocrine organs leads to impaired growth hormone secretion, diabetes mellitus, hypothyroidism, hypoparathyroidism, lack of sex steroids and vitamin D deficiency that contribute t...
متن کاملTransfusion Related Adverse Effects on Beta-Thalassemia Major and New Therapeutic Approaches: A Review Study
Thalassemia is one of the most common genetic disorders, worldwide.Beta-Thalassemia Major (BTM) is the most severe type, which reduces lifeexpectancy and quality of life. In this study, we searched the related keywords to subject from 1996-2019 in the Medline and Web of Science databases, therefore found 250 articles. Moreover, we categorized them into the studies on blood transfusions in...
متن کاملprevalence of alloantibodies and autoantibodies in transfusion dependent thalassemia patients
background: the development of anti-red blood cell alloantibodies remains a major problem in transfusion of blood in thalassemia major patients. also, autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. we studied the frequency of red blood cell alloimmunization and autoimmunization among thalassemia patients who received regular transfusions in ilam province...
متن کاملPrevalence and specificities of red cell alloantibodies in transfusion-dependent beta thalassemia patients in Yazd
Abstract Background Multiple transfusions in thalassemia patients may lead to antibody production against blood group antigens and hemolytic transfusion reaction might occur. In this study, antibody screening test was performed by tube and gel methods to determine the prevalence and specificity of alloantibodies in thalassemia patients. Materials and Methods In this cross-sectional study, overa...
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ژورنال
عنوان ژورنال: Hematology
سال: 2017
ISSN: 1520-4391,1520-4383
DOI: 10.1182/asheducation-2017.1.278